English to Russian Medical Medical: Pharmaceuticals

Examples include an increase in a pleural effusion from “trace” to “large”, an increase in lymphangitic disease from localized to widespread, or may be described in protocols as “sufficient to require a change in therapy”.
If “unequivocal progression” is seen, the patient should be considered to have had overall PD at that point.
While it would be ideal to have objective criteria to apply to nonmeasurable disease, the very nature of that disease makes it impossible to do so; therefore, the increase must be substantial.