Zebra body myopathy
Dutch translation: zebra body-myopathie
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| 12:35 Nov 12, 2010 |
| English to Dutch translations [PRO] Medical - Medical (general) | |||||||
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|  Selected response from: Barend van Zadelhoff Netherlands Local time: 01:10 | ||||||
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| Summary of answers provided | ||||
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| 4 | zebra body-myopathie |
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| 3 | myopathie van de lamellaire lichaampjes |
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| Discussion entries: 8 | |
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Answers
1 hr confidence: 
| zebra body myopathy myopathie van de lamellaire lichaampjes Explanation: Of "keratinosomen"/"odland-bodies" i.p.v. lamellaire lichaampjes. Zoeist wordt wellicht toch bedoeld? |
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1 day 6 hrs confidence:
| zebra body myopathy zebra body-myopathie Explanation: Bekend is, neem ik aan dat "myopathie" "spieraandoening" betekent. Daar kunnen allerlei oorzaken aan ten grondslag liggen: endocrien, genetisch, metabool, carcinogeen, etc bij zebra body myopathy gaat het volgens mijn referentie om een mogelijk congenitale spieraandoening, dat betekent in dit geval door overerving verkregen. Het dus om een mogelijk genetische spieraandoening. ik heb antwoord gevonden op iets wat ik niet helemaal kon plaatsen: ik twijfelde steeds of het om "echte" zebra bodies ging, d.w.z. zoals ze worden gedefinieerd. Het blijkt inderdaad om "zebra bodies" ("zebra bodies" tussen aanhalingstekens) te gaan: ■Zebra body myopathy: Only 2 congenital-onset cases have been reported and were characterized by hypotonia and weakness that progressed slowly or was nonprogressive. On EM, zebra bodies are characterized by Z-band material connected by fine filaments in a pseudosarcomeric pattern, resulting in a striped appearance. Zebra bodies are normally present in myotendinous junctions, intrafusal fibers, extrafusal fibers, extraocular muscle, and cardiac muscle. Their function is unknown. http://emedicine.medscape.com/article/1175852-overview#rarec... het gaat dus niet om "membraneuze gangliosiden" maar om materiaal dat zich in spiervezels (= spiercellen) vormt en er onder de electronenmiscroscoop streperig uitziet: Z-band material connected by fine filaments in a pseudosarcomeric pattern, resulting in a striped appearance. de vorming van dit materiaal in spiercellen/vezels uit zich dan in minder goed functionerende spieren: spieraandoening de diagnose komt dus tot stand op basis van de histochemie van de aandoening |
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