Glossary entry (derived from question below)
English term or phrase:
gene silencing
Serbian translation:
utišavanje gena
Feb 9, 2010 13:59
14 yrs ago
English term
gene silencing
GBK
English to Serbian
Science
Biology (-tech,-chem,micro-)
Definition from
MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells.
Example sentences:
Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. (biotech-info.net)
The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? (The Thomson Corporation)
In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. (ScienceDaily LLC)
Proposed translations
(Serbian)
| 4 +2 | utišavanje gena |
Milan Djukić
|
| 5 | gubitak ekspresije gena |
Natasa Djurovic
|
Change log
Feb 9, 2010 13:01: changed "Kudoz queue" from "In queue" to "Public"
Feb 9, 2010 13:59: changed "Stage" from "Preparation" to "Submission"
Feb 12, 2010 15:08: changed "Stage" from "Submission" to "Selection"
Apr 10, 2010 15:54: changed "Stage" from "Selection" to "Completion"
Proposed translations
+2
7 hrs
Milan Djukić
Serbia
Serbia
Serbia
Accurate IT/sci/tech translations
Native in: Serbian
Works in: English to Serbian, English to Bosnian, English to Croatian, and 3 more.
Related KudoZ points
:
8
Selected
utišavanje gena
Definition from
own experience or research:
Utišavanje gena se koristi pri isključivanju gena mehanizmima različitim od genetske modifikacije, a koji su povezani sa epigenetikom, odnosno regulacijom gena kroz delovanje faktora okoline. Gen koji bi u normalnim okolnostima bio aktiviran je u utišavanju gena nužno isključen, a glavni uzrok tome je RNK interferencija.
Example sentences:
Epigenetske modifikacije dovode do promena genske ekspresije bez uticaja na sekvencu DNK. DNK metilacija je oblik epigenetske modifikacije, gde hipermetilacija CpG ostrvaca promotora dovodi do transkripcionog utišavanja gena i maligne transformacije. (Društvo genetičara Srbije)
Bazična nauka je i ranije bila upoznata sa procesom post-transkripcionog utišavanja gena. Ipak, iako su mnogi enzimi bili poznati, tek otkrivanje RNAi je omogućilo da se stvori potpuna slika o preciznosti i mogućnostima regulisanja ekspresije pojedinih gena. Koliko je RNAi odgovorna za epigenetske procese je i dalje u centru pažnje mnogih naučnih grupa. No, ono što je bilo najinteresantnije kada je fenomen RNAi razjašnjen je njen potencijal za genetska istraživanja. Utišavanje gena je veoma elegantan i precizan način da se izučava njegova funkcija bez previše neželjenih efekata. Takodje, moguće je i regulisati specifičan gen u specifično vreme i u odredjenim ćelijama. (Stetoskop.info)
"Utišavanjem gena mogu da se analiziraju ponašanje miša i fiziološke promene do kojih dolazi, a tako može da se zaključi kakva je normalna funkcija tog gena", kaže Goldberg. (Politika)
4 KudoZ points awarded for this answer.
4 hrs
Natasa Djurovic
Serbia
Serbia
Serbia
Certified translator
Native in: Serbian 
Works in: English to Serbian, Serbian to English, English to Serbo-Croat, and 5 more.
Related KudoZ points
:
14
gubitak ekspresije gena
Gene silencing je dat pod silencing u Serbglos-u, Biotehnoloski recnik.
Definition from
own experience or research:
Gubitak ekspresije gena uzrokovan je mutacijom u sekvenci DNK strukturnog gena.
Example sentences:
Gubitak ekspresije gena, bilo kroz izmenu u sekvenci DNK strukturnog gena ili njegovog regulacionog regiona; ili zbog interakcije izmedju njegovog transkripta i drugih mRNK (a) prisutnih u celiji. (http://www.fao.org/biotech/docs/serbglos)
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