Wikipedia:

University president

University president is the title of the highest-ranking officer within the academic administration of a university, within university systems that prefer that appellation over other variations such as chancellor or rector. The relative seniority varies between institutions.
United Kingdom

In Northern Ireland, the president is the chief academic and administrative officer of the university and is usually also the vice-chancellor of the university.
United States

In most stand-alone universities and colleges in the United States, the chief executive officer is called the President, while the second in command is called the Provost. In some multi-campus state university systems, the chancellor has authority over all universities in the system, and therefore ranks higher than the presidents of individual universities within the system. In other state university systems, the president has authority over multiple campuses, each of which is headed by a chancellor who is under the authority of the president.

http://en.wikipedia.org/wiki/Chancellor_(education)

It depends where you are and who the translation is for...

Normalmente não há tantos cargos em empresas nos EUA quanto nas empresas no Brasil. O Diretor-Geral é conhecido como CEO (Cheif Executive Officer), e esse termos "engloba" o cargo como um todo.